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Last Updated: 2 years ago

Possible Interaction: Quinine and Sulpiride

supplement:

Quinine

Research Papers that Mention the Interaction

Local perfusion with quinine , a K+ channel blocker, completely blocked the (—)‐sulpiride‐induced increases in DA but did not affect the DA agonist‐induced decreases.
Journal of neurochemistry  •  1992  |  View Paper
Pimozide (4mg/kg, ip), L-sulpiride (40mg/kg, ip), SCH 23390 (0.2mg/kg, sc) and alpha-methyl-p-tyrosine (50mg/kg, ip) effectively potentiated the antinociceptive effects of quinine (50mg/kg, ip).
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  1992  |  View Paper
On the other hand, pimozide (0.2 mg/kg intraperitoneally), L-sulpiride (40 mg/kg intraperitoneally and SCH 23390 (0.2 mg/kg subcutaneously) potentiated the locomotor depressant effect of high doses of quinine (1-5 mg/kg) intraperitoneally).
Pimozide (4 mg/kg intraperitoneally) and L-sulpiride (40 mg/kg intraperitoneally) antagonized both the circling and increase in locomotor activity induced by quinine (0.1 mg/kg intra peritoneally) and D-amphetamine (4 mg/kg intraperitoneally) respectively.
Journal of psychopharmacology  •  1989  |  View Paper