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Last Updated: 3 months ago

Possible Interaction: Quinine and Rifampin

supplement:

Quinine

Research Papers that Mention the Interaction

Rifampin should not be combined with quinine for the treatment of malaria, and the doses of quinine should probably be increased in patients who are already receiving rifampin treatment.
Rifampin significantly increases the metabolic clearance of quinine and thereby reduces cure rates.
Antimicrobial Agents and Chemotherapy  •  2003  |  View Paper
The mean elimination half-life of quinine when coadministered with rifampicin (5.5 +/- 3.0 h) was significantly shorter than when quinine was given alone (11.1 +/- 3.0 h; the 95% C.I. for the mean difference was -8.6 to -2.6).
The unbound clearance (CLu/F) of quinine, which reflects the …, was considerably greater (6.9-fold) in subjects when rifampicin … quinine than that of quinine alone (6.9 +/- 3.6 vs 1.0 +/- 0.5 …; the 95% C.I. for the mean difference was 3.3 to 8.5).
clearance (CL/F) of quinine coadministered with rifampicin (0.87 +/- 0.35 1 h-1 kg-1) was significantly greater than that of quinine alone (0.14 +/- 0.05 1 h-1 kg-1).
British journal of clinical pharmacology  •  1995  |  View Paper
Quinine is mainly metabolized by the cytochrome P450 3A4 isozyme (CYP3A4), whereas rifampin , a potent inducer of CYP3A4, is known to markedly decrease plasma quinine concentration.
The Journal of pharmacy and pharmacology  •  2000  |  View Paper
Our previous studies have shown that cigarette smoking and rifampicin pretreatment enhance the elimination of quinine , metabolism assumed, by analogy with quinidine, to be carried out by CYP3A (P450IIIA).
The Journal of pharmacy and pharmacology  •  1995  |  View Paper