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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Quinine and Lopinavir

supplement:

Quinine

Research Papers that Mention the Interaction

LPV/r significantly decreased the exposure of quinine and its major active metabolite, 3‐hydroxyquinine, in both total and free (unbound) forms.
These findings highlight the complex nature of the influence exerted by LPV/r on several of the drug‐metabolizing enzymes involved in quinine disposition, including CYP3A4, UDP‐glucuronosyltransferase (UGT), and P‐glycoprotein (P‐gp).
Clinical pharmacology and therapeutics  •  2012  |  View Paper