“ LPV/r significantly decreased the exposure of quinine and its major active metabolite, 3‐hydroxyquinine, in both total and free (unbound) forms.”
“These findings highlight the complex nature of the influence exerted by LPV/r on several of the drug‐metabolizing enzymes involved in quinine disposition, including CYP3A4, UDP‐glucuronosyltransferase (UGT), and P‐glycoprotein (P‐gp).”