Possible Interaction: Quinine and Iron, Dietary

“Rats deficient in calcium, iron and zinc also showed elevated proportional levels of quinine sulfate ingestion compared to controls suggesting that a pica may be a general response to nutritional deficiency.”

“Differential pulse voltammetry showed an anodic shift of the iron redox potential if iron was liganded by QUIN.”

“In lower concentrations, we show that by liganding iron, QUIN affects the Fe(II)/Fe(III) ratios that are beneficial to homeostasis.”

“ QUIN can form coordination complexes with iron.”

“Thus, we propose that redox cycling of iron by a Quin derivative, formed by initial attack of hydroxyl radicals on Quin, rather than effects of iron complexes on DMPO-OH stability or redox cycling by hydrogen peroxide, is responsible for enhanced DMPO-OH signal in the presence of Quin.”