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Last Updated: 7 months ago

Possible Interaction: Quinine and Halofantrine

supplement:

Quinine

Research Papers that Mention the Interaction

Qinghaosu derivatives were more efficient than other antimalarial drugs, but a positive correlation was observed between the 50% inhibitory concentrations of halofantrine and quinine and the number of adhesive parasitized red blood cells, suggesting their influence on cytoadherence.
The American journal of tropical medicine and hygiene  •  2000  |  View Paper
The response to halofantrine was positively correlated with the responses to quinine and mefloquine, in the case of chloroquine and halofantrine an inverse relationship was observed.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit  •  1994  |  View Paper
In conclusion, we showed that quinine and quinidine coadministered with HF might inhibit its metabolism resulting in the potentiation of HF-induced cardiotoxicity in patients.
Mefloquine, quinine , quinidine, and ketoconazole used at maximal plasma concentrations inhibited N-debutylhalofantrine formation noncompetitively with Ki values of 70 microM, 49 microM, 62 microM, and 0.05 microM resulting in 7%, 49%, 26%, and 99% inhibition, respectively, in HF metabolism.
Drug metabolism and disposition: the biological fate of chemicals  •  1999  |  View Paper
A marked resistance to halofantrine is shown by parasites resistant to mefloquine, quinine , chloroquine and amodiaquine, although the moderately chloroquine-resistant 'NS line' is sensitive.
Annals of tropical medicine and parasitology  •  1987  |  View Paper