Possible Interaction: Quinine and Doxorubicin Hydrochloride

“Addition of ADM and ADW to quinine caused reduction in bitterness intensity, with IC50 values of 420.32 ± 6.26 μM and 403.29 ± 4.10 μM, respectively.”

“Polarised transport of doxorubicin in the Caco-2 and the LLC-PK1:MDR1 cell lines could be inhibited by the P-gp inhibitors SDZ-PSC 833 (PSC 833), cyclosporin A (CsA), verapamil and quinine , but not by the inhibitors for the organic cation carrier systems cimetidine and tetraethylammonium (TEA).”

“Non-toxic concentrations (5-20 microM) of chloroquine, quinine , quinidine, and primaquine potentiated the toxicity of doxorubicin in a concentration-dependent manner.”

“ Quinine also modified the intracellular tolerance to doxorubicin , which suggests that it is able to modify drug distribution within the cells.”

“In serum-free medium, quinine induced a dose-dependent increase of doxorubicin uptake reaching about 200% at 40 microM, while it had a slight and no effect on mitoxantrone and vincristine uptake respectively.”

“At these concentrations, quinine induces a more than double increase in ADM uptake in K562/ADM cells.”

“In culture medium, quinine is slightly less effective than verapamil in increasing the cytotoxicity and uptake of ADM when both drugs are used at the same concentration.”

“At each dose level of verapamil tested, the combination with quinine proved more effective than either drug individually in reversing resistance to doxorubicin and vinblastine and synergistic chemosensitizing interaction was observed.”

“In culture medium, quinine (5 mu/ml or more) significantly increases cytotoxicity and accumulation of DXR in the resistant cells but not in the parental sensitive cells.”