Possible Interaction: Quinine and Calcium Supplement

“Rats deficient in calcium , iron and zinc also showed elevated proportional levels of quinine sulfate ingestion compared to controls suggesting that a pica may be a general response to nutritional deficiency.”

“Since both … and quin 2 may reduce … concentration of cytoplasmic Ca++ , the former by raising cyclic AMP (cAMP) levels and the latter by acting as a Ca++ buffer, the results … further evidence for the involvement of Ca++ in the responses of large vein endothelial cells to inflammatory agentsin vitro.”

“Taken together, these results demonstrate that quinine inhibits CA secretion evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization through inhibiting influx of extracellular calcium and release in intracellular calcium in the rat adrenomedullary chromaffin cells.”

“ Quinine also abolished the hyperpolarization which was evoked by intracellular injection of calcium ions.”

“The observations indicate that calcium ions are able to reverse the cardiodepression induced by chloroquine and quinine.”

“ Quinine caused a dose-related inhibition of the translocation of Ca from an aqueous medium into an organic immiscible phase, as evoked by either the antibiotic ionophore X537A or an islet extract.”

“Both quinine and lanthanum strongly inhibited the normal uptake of calcium by ileal muscle from the extracellular medium.”