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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Quinine and Artesunate



Research Papers that Mention the Interaction

In some areas clinicians have combined parenteral artesunate and quinine in the belief that the 2 drugs would be additive or synergistic in severe malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene  •  2001  |  View Paper
Mortality was 15% in the artesunate group and 22% in the quinine group, a reduction of 34.7% (95% confidence interval: 18.5–47.6%) in the artesunate group , with almost all the benefit reported in those with high parasite counts.
Expert review of anti-infective therapy  •  2007  |  View Paper
The geometric mean 50% inhibitory concentration (IC50) values from primary infections were: dihydroartemisinin 1.2 ng/mL, artesunate 1.6 ng/mL, artemether …/mL, mefloquine 27 ng/mL and halofantrine 4.1 ng/mL. A significant positive correlation was found between the susceptibility in vitro to artesunate … quinine (r = …).
Transactions of the Royal Society of Tropical Medicine and Hygiene  •  2000  |  View Paper
Artesunate and artemether were more potent than quinine in inhibiting both adherence properties.
The Journal of infectious diseases  •  1996  |  View Paper
Empirical addition of parenteral quinine to artesunate for treatment is recommended as a precautionary measure.
Malaria Journal  •  2018  |  View Paper
Treatment with quinine has been described as a risk factor; however the syndrome may also occur following treatment with intravenous artesunate.
Malaria Journal  •  2016  |  View Paper
ConclusionsThe great majority of P. falciparum isolates in the Brazilian malaria-endemic area remain resistant to chloroquine, and the decreased sensitivity to quinine , mefloquine and artesunate observed in 10–20% of the isolates must be taken with concern, especially for artesunate.
Malaria Journal  •  2013  |  View Paper
To delay the emergence of resistance, ‘… drugs (mefloquine and halofantrine and perhaps quinine ) may not be the best candidates since … evidence of cross resistance between them and artesunate in vitro’ (L.K. Basco and J. Le Bras, In vitro … artemisinin derivatives against African isolates and clones of Plasmodium falciparum.
Parasitology today  •  2000  |  View Paper