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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Quinine and Artemisinin

supplement:

Quinine

Research Papers that Mention the Interaction

Within therapeutically relevant molar ratios (19 to 200), the combination of quinine and artemisinin showed mean ΣFICs of 1.71 at the EC50, 0.36 at the EC90, and 0.13 at the EC99, indicating increasing synergism.
Antimicrobial Agents and Chemotherapy  •  2002  |  View Paper
BACKGROUND Quinine and artemisinin drugs are used in severe malaria, but quinine resistance is increasing.
The Cochrane database of systematic reviews  •  2004  |  View Paper
A positive correlation between IC50S of artemisinin and those of quinine , mefloquine and halofantrine was observed.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit  •  1992  |  View Paper
In view of this background and reported anti malaria synergism between artemisinin and quinine ; we describe the computer-assisted docking to predict molecular interaction and binding affinity of Artemisinin-Quinine hybrid and its derivatives with the intraparasitic haeme group of human haemoglobin.
Bioinformation  •  2012  |  View Paper
Synergism between artemisinin derivatives and QN has been shown in vitro and in vivo: Q.L. Fivelman et al., The effect of artesunate combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro.
Parasitology today  •  2000  |  View Paper