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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinine
drug:
Artemisinin
Research Papers that Mention the Interaction
“Within therapeutically relevant molar ratios (19 to 200), the combination of quinine and artemisinin showed mean ΣFICs of 1.71 at the EC50, 0.36 at the EC90, and 0.13 at the EC99, indicating increasing synergism.”
In Vitro Interactions of Artemisinin with Atovaquone, Quinine, and Mefloquine against Plasmodium falciparum“BACKGROUND Quinine and artemisinin drugs are used in severe malaria, but quinine resistance is increasing.”
“A positive correlation between IC50S of artemisinin and those of quinine , mefloquine and halofantrine was observed.”
Susceptibility of African isolates of Plasmodium falciparum to artemisinin (qinghaosu).“In view of this background and reported anti malaria synergism between artemisinin and quinine ; we describe the computer-assisted docking to predict molecular interaction and binding affinity of Artemisinin-Quinine hybrid and its derivatives with the intraparasitic haeme group of human haemoglobin.”
Molecular modeling and evaluation of binding mode and affinity of artemisinin-quinine hybrid and its congeners with Fe-protoporphyrin-IX as a putative receptor“Synergism between artemisinin derivatives and QN has been shown in vitro and in vivo: Q.L. Fivelman et al., The effect of artesunate combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro.”
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