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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Quinidine and Vincristine

supplement:

Quinidine

Research Papers that Mention the Interaction

Quinidine also enhanced the cellular accumulation of VCR in P388/VCR cells in vivo.
Quinidine increased the cellular levels of VCR and daunomycin in VCR-resistant sublines of mouse and human tumors and the ADM-resistant mouse tumor line in vitro, respectively.
Quinidine , which has antiarrhythmic activity, greatly enhanced the cytotoxicity of vincristine (VCR) in tumor cells and especially in VCR-resistant sublines of P388 leukemia (P388/VCR) and human myelogenous leukemia.
When administered daily for 10 days with VCR, quinidine at doses of 50 to 125 mg/kg significantly enhanced the chemotherapeutic effect of VCR in P388/VCR-bearing mice.
Cancer research  •  1984  |  View Paper