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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinidine
drug:
Vinblastine
Research Papers that Mention the Interaction
“ Quinidine is known to inhibit p-glycoprotein and enhance the activity of vinblastine against cultured renal carcinoma cells.”
Evaluation of the Combination of Vinblastine and Quinidine in Patients with Metastatic Renal Cell Carcinoma: A Phase I Study“Like verapamil (10 μM) itself, three of the other …, namely, S9788 (4 μM), flunarizine (20 μM) and quinidine (30 μM), resulted in … 3-fold sensitization of vinblastine against the parental CEM cells, and comparable effects were noted in … CEM/VM-1 cells, which were not cross-resistant to vinblastine.”
“This fraction inhibited the efflux of vinblastine from MDR cells, and also inhibited the photoaffinity labeling of P-gp with azidopine as effectively as vinblastine, quinidine and cepharanthine.”
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