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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Quinidine and Venlafaxine

supplement:

Quinidine

Research Papers that Mention the Interaction

In extensive metabolizers, quinidine decreased venlafaxine oral clearance from 100 +/- 62 l/h to 17 +/- 5 l/h (mean +/- SD; P < 0.05) without any effects on renal clearance (4 +/- 1 l/h during venlafaxine alone and 4 +/- 1 l/h during venlafaxine plus quinidine).
Pharmacogenetics  •  1999  |  View Paper
quinidine to EMs resulted in an … partial metabolic clearance of (R)-venlafaxine to O-demethylated metabolites [127 (10-493) l/h down to 1 (0.1-3) l/h, 0.05], … was measured for (S)-venlafaxine [47 (14-94) l/h versus 7 (1-19) l/h, 0.05].
Pharmacogenetics  •  2003  |  View Paper