Discover Supplement-Drug Interactions
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2 months ago
Possible Interaction: Quinidine and Tropisetron
Research Papers that Mention the Interaction
“Results showed that the oxidation of all three compounds involved CYP2D6, but only that of
was inhibited by over 90% in the presence of
Use of electrospray ionization liquid chromatography-mass spectrometry to study the role of CYP2D6 in the in vitro metabolism of 5-hydroxytryptamine receptor antagonists.
Journal of chromatography. B, Biomedical applications • 1996 |
(0.5 microM) inhibited 5- and 6-hydroxylation at 10-80 microM
competitively by 70% with Ki values of 10 and 18 nM, respectively.”
In vitro characterization of cytochrome P450 catalysed metabolism of the antiemetic tropisetron.
Biochemical pharmacology • 1995 |
“The cytochrome P-450 (CYP) 2D6 inhibitor
(1 microM) reduced the hydroxylation of
(67%) and ondansetron (18%).”
The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron.
Drug metabolism and disposition: the biological fate of chemicals • 1994 |
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