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Last Updated: 2 months ago

Possible Interaction: Quinidine and Tropisetron

supplement:

Quinidine

Research Papers that Mention the Interaction

Results showed that the oxidation of all three compounds involved CYP2D6, but only that of tropisetron was inhibited by over 90% in the presence of quinidine.
Journal of chromatography. B, Biomedical applications  •  1996  |  View Paper
Quinidine (0.5 microM) inhibited 5- and 6-hydroxylation at 10-80 microM tropisetron concentrations competitively by 70% with Ki values of 10 and 18 nM, respectively.
Biochemical pharmacology  •  1995  |  View Paper
The cytochrome P-450 (CYP) 2D6 inhibitor quinidine (1 microM) reduced the hydroxylation of tropisetron (67%) and ondansetron (18%).
Drug metabolism and disposition: the biological fate of chemicals  •  1994  |  View Paper