“In conclusion, the inhibition of timolol metabolism by quinidine should be taken into account when patients are treated with timolol.”
“The CYP2D6 inhibitor quinidine proved a potent competitive inhibitor of timolol metabolism, with an in vitro Ki value of 0.08 μM. Fluvoxamine, an inhibitor of CYP2C19, inhibited timolol metabolism to a lesser extent, confirming its minor contribution.”