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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinidine
drug:
Theophylline
Research Papers that Mention the Interaction
“ Quinidine inhibited the intestinal exsorption of theophylline and S‐disopyramide possibly by competition on the carrier.”
Concentration‐dependent Exsorption of Quinidine in the Rat Intestine“Co‐administration of theophylline (0 −2 mg h−1) with the test agents increased the CLi of salicylic acid, did not alter the CLi of urea, but decreased the CLi of quinidine.”
“The effect of theophylline on the CLi of quinidine was enhanced with increasing dose.”
“ Theophylline may also affect quinidine CLi by inhibiting the carrier‐mediated pathway.”
“Co‐administration of theophylline with quinidine decreased the CLi of quinidine without affecting quinidine binding in serum or in the perfusate.”
“ Quinidine (over 5 X 10(‐5) M) inhibited and theophylline (over 5 X 10(‐4) M) enhanced the ATP response, with associated depolarization or hyperpolarization of the membrane, respectively.”
“ Quinidine , 0·1 to 1·0 mM, antagonized the lipolytic activity of theophylline but either enhanced, antagonized or had no effect on the lipolytic activity due to dibutyryl cyclic AMP depending upon the experimental conditions.”
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