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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinidine
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“The combination of similarly low concentrations of tetrodotoxin and quinidine also produced enhanced anti-arrhythmic efficacy and enhanced prolongation of ventricular refractoriness and conduction which mimicked the effect of mexiletine and quinidine in combination.”
Mexiletine-quinidine in isolated hearts: an interaction involving the sodium channel.“Under voltage clamp condition, quinidine reduced peak inward current in the absence of TTX, but enhanced peak inward current in the presence of TTX.”
“Although the Na+/H+ exchange activity was not inhibited by tetrodotoxin or digitoxin, it was inhibited by quinidine , quinacrine, amiloride, and several amiloride derivatives.”
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