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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“This so-called 'reverse use dependence' can … overcome with certain drug combinations, such as sotalol plus … quinidine or procainamide, drugs with multi-channel blocking properties, such as amiodarone, and possibly with drugs which … the I(Ks) as well as the I(Kr) potassium current, such as azimilide and ambasilide.”
Mechanisms of action of class III agents and their clinical relevance.“Although sotalol alone decreased the maximum rate of depolarization of phase 0 of the AP (Vmax) by only 3 +/- 2% (p = NS), sotalol attenuated Vmax decrease of quinidine (at 3 Hz) from 40 +/- 4 to 16 +/- 3% (p < 0.05).”
“ Quinidine + sotalol prolonged ERP (at 3 Hz) by 27 +/- 2% as compared with 11 +/- 2% after sotalol and 18 +/- 2% after quinidine alone (p < 0.05).”
“The combination of quinidine and sotalol is very effective in prevention of recurrent sustained ventricular tachycardia (SVT).”
Cellular mechanism underlying the efficacy of the sotalol-quinidine combination.“No adverse haemodynamic effects of dofetilide, sematilide or d-sotalol were observed, but quinidine induced marked cardiac depression and racemic sotalol also impaired left ventricular contractility.”
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