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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinidine
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“According to the modulated receptor theory, it is probable that salicylate decreases the dissociation constant for quinidine binding to inactivated-state channels.”
“Salicylate enhanced the quinidine-induced tonic and use-dependent block of … (HP) of -100 mV but not at -140 mV. Salicylate decreased the IC50 value for the quinidine-induced tonic block of hH1 at an … shift in the steady-state inactivation curve of hH1 in the presence of quinidine.”
“The results suggest that salicylate enhances quinidine-induced block of Na+ channels via increasing the affinity of quinidine to inactivated state channels.”
Enhancing effects of salicylate on quinidine-induced block of human wild type and LQT3 related mutant cardiac Na+ channels.“Displacement of quinidine by salicylic acid was nonlinear; the extent of displacement increased with increasing total quinidine concentrations.”
“The addition of therapeatic concentrations of salicylic acid , phenylbutazone, and tolbutamide significantly reduced quinidine binding (p < 0.025), but 10 other commonly coadministered drugs did not.”
“ Salicylate enhanced the tonic and phasic block of Vmax induced by quinidine , aprindine and disopyramide but had little effect on that induced by procainamide or mexiletine; the enhancing effects were related to the liposolubility of the drugs.”
Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle.
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