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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Quinidine and Rifampin

supplement:

Quinidine

Research Papers that Mention the Interaction

Rifampin treatment significantly increased the oral clearance of each drug from 1.4-fold (valproic acid) to 3.4-fold ( quinidine).
Xenobiotica; the fate of foreign compounds in biological systems  •  1993  |  View Paper
Studies and case reports have demonstrated that rifampin accelerates the metabolism of several drugs, including oral anticoagulants, oral contraceptives, glucocorticoids, digitoxin, quinidine , methadone, hypoglycemics, and barbiturates.
Archives of internal medicine  •  1984  |  View Paper
Serum drug concentration data from the first of the two patients described herein suggest that rifampin may directly increase the metabolism of quinidine and thereby negate the influence of quinidine on the serum digoxin concentration (SDC).
Archives of internal medicine  •  1984  |  View Paper
However, only ∼40% inhibition of P-gp-mediated efflux of quinidine was observed with coperfusion of rifampin , even at a 2-fold higher rifampin concentration (1000 μM).
Journal of Pharmacology and Experimental Therapeutics  •  2003  |  View Paper