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Last Updated: 2 years ago

Possible Interaction: Quinidine and Quinine

supplement:

Quinidine

supplement:

Quinine

Research Papers that Mention the Interaction

Both red cell and plasma levels of quinine-quinidine were higher than quinine levels.
Annals of tropical paediatrics  •  1991  |  View Paper
Quinidine exhibited stronger inhibition than quinine ; however, these two compounds inhibited the CYP2D6.10-mediated reaction more weakly than the CYP2D6.1 and CYP2D6.2 reactions.
Archives of biochemistry and biophysics  •  2017  |  View Paper
The Lineweaver-Burk plots with varying inhibitor concentrations suggested that inhibition by quinidine and quinine was competitive.
Xenobiotica; the fate of foreign compounds in biological systems  •  2001  |  View Paper
Thus, the dog expresses a CYP2D ortholog possessing enzymatic activities similar to human CYP2D6, but is affected by the inhibitors quinine and quinidine in a manner closer to that of rat CYP2D1.
Archives of biochemistry and biophysics  •  1998  |  View Paper
The mean trough level of quinidine (10 mumol/l) was about 2.5-times less than that of quinine (25 mumol/l).
Bulletin of the World Health Organization  •  1988  |  View Paper
The risks of fast intravenous injection of quinine , the striking prolongation of the electrocardiographic (ECG) QT interval triggered by quinidine , and the lethality of CQ in overdose have separately caused substantial concern.
European heart journal. Cardiovascular pharmacotherapy  •  2020  |  View Paper
Though common with other potassium channel blockers (ezogabine and quinine ), such discoloration has only rarely been reported with quinidine, all in adults.2 Epileptologists should be aware of this potential complication of quinidine therapy.
Neurology  •  2017  |  View Paper
Moreover, quinidine blocks the entrance of the active pocket of CYP2D6 more closely than quinine does, which explains well why the inhibitory activity of quinidine is of 2 magnitudes larger than quinine.
Bioorganic & medicinal chemistry letters  •  2009  |  View Paper
Crossreactivity between quinine and quinidine photoallergy has been reported, but not with chloroquine.
Tropical doctor  •  2005  |  View Paper
In conclusion, we showed that quinine and quinidine coadministered with HF might inhibit its metabolism resulting in the potentiation of HF-induced cardiotoxicity in patients.
Drug metabolism and disposition: the biological fate of chemicals  •  1999  |  View Paper
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