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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinidine
drug:
Paliperidone
Research Papers that Mention the Interaction
“This observation is confirmed by the findings that both quinidine (inhibitor of CYP2D6) and ketoconazole (inhibitor of CYP3A4) can inhibit the formation of 9-hydroxyrisperidone.”
Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4“The use of paliperidone should be avoided in combination with other drugs that are known to prolong QTc, including Class 1A ( quinidine , procainamide) or Class III (amiodarone, sotalol) antiarrhythmic medications, antipsychotic medications (chlorpromazine, thioridazine), antibiotics (gatifloxacin, moxifloxacin), or any other class of agents known to prolong the QTc interval.”
Pharmaceutical approval update.
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