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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“Coadministration of quinidine and naloxegol increased naloxegol's AUC 1.4‐fold and Cmax 2.5‐fold but did not antagonize morphine‐induced miosis, suggesting that PGP inhibition does not increase the CNS penetration of naloxegol.”
“The observed increase in exposure to naloxegol in the presence of quinidine is primarily attributed to quinidine's properties as a weak CYP3A inhibitor.”
The effect of quinidine, a strong P‐glycoprotein inhibitor, on the pharmacokinetics and central nervous system distribution of naloxegol“The authors attributed the observed increase in exposure to naloxegol to quinidine’s … 3A (CYP3A) inhibitor.1 The authors concluded that the concomitant administration of naloxegol … quinidine , a CYP3A inhibitor and PGP transporter inhibitor, increases overall naloxegol exposure … not appear to cross into the CNS at clinically relevant concentrations.”
“The authors found that “coadministration of quinidine and naloxegol increased naloxegol AUC 1.4-fold and Cmax 2.5-fold but did not antagonize morphine-inducedmiosis, suggesting that P-Glycoprotein (PGP) inhibition does not increase the CNS penetration of naloxegol.””
“Observed changes were predicted in the models in naloxegol exposure with ketoconazole, diltiazem, rifampin, and quinidine.”
Highlights
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