“AIMS To test the hypothesis that the renal clearance of moxonidine decreases when dosed with quinidine.”
“RESULTS When coadministered, qu nidine si gnificantly increased mox onidine AU C and t1/2 by 11% and 15%, respectively, and decreased CL/F by 10% compared with the control dosing.”
“The decrease in apparent total clearance of moxonidine with quinidine coadministration was possibly due to metabolic inhibition, though not likely to be clinically significant.”