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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Quinidine and Moxonidine

supplement:

Quinidine

Research Papers that Mention the Interaction

AIMS To test the hypothesis that the renal clearance of moxonidine decreases when dosed with quinidine.
RESULTS When coadministered, quinidine significantly increased moxonidine AUC and t1/2 by 11% and 15%, respectively, and decreased CL/F by 10% compared with the control dosing.
The decrease in apparent total clearance of moxonidine with quinidine coadministration was possibly due to metabolic inhibition, though not likely to be clinically significant.
British journal of clinical pharmacology  •  2002  |  View Paper