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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quinidine
drug:
Loratadine
Research Papers that Mention the Interaction
“ Quinidine (5 microm), a CYP2D6 inhibitor, inhibited the formation … approximately 20% when added to microsomal incubations of loratadine at concentrations of 7-35 microM. Incubation of loratadine with cDNA-expressed CYP3A4 and CYP2D6 microsomes … formation of DCL with formation rates of 135 and 633 pmol/min/nmol P450, respectively.”
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
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