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Last Updated: 3 years ago

Possible Interaction: Quinidine and Calcium Supplement



Research Papers that Mention the Interaction

Using isolation cell procedure and whole cell recording, we found that 10 μM quinidine (34.77±6.5%, n=5) and 0.5 μM flecainide (50.46±6.2%, n=4) decrease calcium current in human atrium.
Basic Research in Cardiology  •  2004  |  View Paper
Oligomycin (10 micrograms/ml) and quinidine (1 mM) inhibit the rate of Ca uptake by inhibiting Ca-induced changes in the K permeability.
The Journal of general physiology  •  1984  |  View Paper
It is concluded that quinidine reduces the membrane conductances for sodium, calcium , and potassium ions.
Journal of cardiovascular pharmacology  •  1979  |  View Paper
Quinidine inhibition is only slightly lessened by Ca+2 so that it appears that the site of action of quinidine may not involve a Ca+2 ion stabilizer.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1961  |  View Paper
Quinidine caused a transient increase in free internal calcium but decreased calcium after a 48 h incubation period.
Biochemical Society transactions  •  2007  |  View Paper
The activity of the high-conductance, Ca2+ -activated, voltage-dependent K+ (BKCa) channel, which is primarily responsible for basolateral K+ recycling during Na+ absorption, was inhibited by 10–30 μM quinidine or propafenone in the form of a rapidly dissociating block.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2005  |  View Paper
Quinidine (>0.5 mmol/l) decreased the Ca2+ uptake (soleus>adductor magnus>papillary muscle) and increased the Ca2+ release [papillary muscle=soleus ≫ adductor magnus (only at 1.5 mmol/l, the highest concentration tested)] from the SR of all three muscles in a dose-dependent manner.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Quinidine , 10 μm, decreased the amplitude of the voltage‐dependent Ca current to only a small extent (15% decrease at 0 mV).
British journal of pharmacology  •  1995  |  View Paper
Quinidine reversibly decreased peak calcium current as well as the slowly inactivating and/or steady-state inward currents in the plateau voltage range, presumably both "late" sodium (tetrodotoxin-sensitive) and calcium (tetrodotoxin-insensitive) currents.
Circulation research  •  1988  |  View Paper
Both the transient and the sustained hyperpolarization evoked in smooth muscle cells in the presence of procainamide (15 min) or quinidine in calcium-containing or in calcium-free solution, respectively, were inhibited.
European journal of pharmacology  •  1987  |  View Paper
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