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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Quinidine and Bretylium

supplement:

Quinidine

Research Papers that Mention the Interaction

Quinidine and procainamide may potentiate the hypotensive effects of bretylium.
American journal of hospital pharmacy  •  1979  |  View Paper
Addition of bretylium to quinidine shortened intraatrial and His-Purkinje conduction times but significantly prolonged intranodal conduction time, resulting in a further prolongation of the total A-V interval.
Subsequent addition of bretylium to quinidine shortened action potential duration and tended to restore the maximal rate of depolarization.
The American journal of cardiology  •  1974  |  View Paper
These data indicate that the electrophysiologic effects of bretylium differ significantly from those of quinidine or lidocaine.
The Journal of pharmacology and experimental therapeutics  •  1972  |  View Paper