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“ Quinidine and disopyramide caused minor delays of repolarization, but both were primarily class 1 agents, and in addition had undesirable anticholinergic activity.”
“The anticholinergic and antiadrenergic actions occur concurrently and are unrelated to the direct action: both of these effects increase in direct relation to the concentration of quinidine.”
“Hence, the direct blockage of the acetylcholine-activated K+ current by quinidine was considered responsible for the anticholinergic action of this drug.”