Possible Interaction: Quinacrine and Phosphatidylethanolamine

“However, mepacrine also interacts directly with membrane phospholipids, primarily phosphatidylethanolamine , to form less polar derivatives.”

“ Quinacrine , an inhibitor of arachidonic acid release from phosphatidylethanolamine , reduced both the stimulation of PGE2 synthesis and the inactivation of prostaglandin cyclooxygenase.”

“Higher concentrations of Mp (0.5 to 1.0 mM) produced a decrease of radioactivity in PE and PC with an increase in PI.”

“32P Incorporation in PtdIns4,5P2, PtdIns PtdEtn and CL was stimulated by quinacrine 50 microM. Under these conditions the LH-stimulated pregnenolone production but not the 25-hydroxycholesterol dependent pregnenolone production, was completely inhibited.”

“ Mepacrine (1 mM) decreased prostaglandin synthesis and both phosphatidylcholine and phosphatidylethanolamine turnover, and had no consistent effect on phosphatidylinositol turnover in control glomeruli.”

“In contrast, mepacrine selectively inhibited the incorporation of both saturated and unsaturated acids into phosphatidylcholine, phosphatidylethanolamine and triglycerides, and concurrently markedly enhanced their incorporation into phosphatidylinositol.”

“The amount of radioactivity in phosphatidylethanolamine was decreased by quinacrine and increased in the vicinity of an unidentified phospholipid-quinacrine complex.”

“ Mepacrine stimulated the labelling of phosphatidic acid, phosphatidylinositol and diacylglycerol, and inhibited that of phosphatidylcholine, phosphatidylethanolamine and triacylglycerol.”