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Last Updated: 8 months ago

Possible Interaction: Quercetin and Warfarin

supplement:

Quercetin

Research Papers that Mention the Interaction

Warfarin reductase activity of both enzymes is not inhibited by pyrazole, sodium barbitone, or dicoumarol, but is strongly inhibited by quercetin , indomethacin, furosemide, and prostaglandin E2 (PGE2).
Drug metabolism and disposition: the biological fate of chemicals  •  1992  |  View Paper
Quercetin metabolites are able to strongly displace warfarin from HSA suggesting that high quercetin doses can strongly interfere with warfarin therapy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2017  |  View Paper
The affinity for this site is large and we found that quercetin may effectively displace warfarin from HSA.
Chirality  •  2010  |  View Paper
Guava leaves extract and quercetin resulted in significant increase in warfarin Cmax when compared to control (p < 0.01).
ResultsPreparations of pomegranate peel guava leaf extract, ellagic acid and quercetin in combination with warfarin were found to exert further significant increase on PT and INR values (p < 0.01) than when used alone (p < 0.05).
Significant reduction in CYP2C8, 2C9, and 3A4 was seen upon concomitant use of warfarin with ellagic acid, guava leaves and quercetin , unlike pomegranate that insignificantly affected CYP activities.
BMC Complementary and Alternative Medicine  •  2019  |  View Paper