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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quercetin
drug:
Vincristine
Research Papers that Mention the Interaction
“The results showed that Que significantly enhanced the antitumor activities of Dox, Pac, and Vcr in breast cancer cells.”
Quercetin reversed MDR in breast cancer cells through down‐regulating P‐gp expression and eliminating cancer stem cells mediated by YB‐1 nuclear translocation“For combination treatment with vincristin (0.375 μmol/L) and quercetin (50 μmol/L), the proliferation rate significantly decreased and apoptosis rate significantly increased.”
“ Quercetin and vincristine are both active against ER− breast cancers and exhibit synergism in vitro.”
“Pentamethyl, pentaethyl, pentapropyl and pentaallyl ethers of morin and quercetin (20 microM) all increased the uptake of [3H]vincristine by K562/ADM cells, while quercetin, morin and their pentabutyl ethers had no effect.”
“In intact MRP1-overexpressing cells, quercetin reduced vincristine resistance from 8.9- to 2.2-fold, whereas kaempferol and naringenin had no effect.”
“These results show that in rats, quercetin may have a protective effect against peripheral neurotoxicity caused by vincristine.”
Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways.“However, treatment of both vincristine and quercetin for a similar period reduced the serum CK-MB, LDH, SGPT and cTnT levels near to normal levels in ISO-treated rats.”
“In conclusion, the present finding appears to be the first one, suggesting a better protection of cardiac tissues by combined treatment of vincristine and quercetin in isoproterenol-induced cardiac toxicity.”
“We conclude that low concentrations of quercetin indirectly activate the transport of [3H]vincristine by enhancing the phosphorylation (and hence activity) of P-glycoprotein, whereas high concentrations of quercetin inhibit P-glycoprotein.”
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