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Last Updated: 8 months ago

Possible Interaction: Quercetin and Vincristine

supplement:

Quercetin

Research Papers that Mention the Interaction

The results showed that Que significantly enhanced the antitumor activities of Dox, Pac, and Vcr in breast cancer cells.
Phytotherapy research : PTR  •  2018  |  View Paper
For combination treatment with vincristin (0.375 μmol/L) and quercetin (50 μmol/L), the proliferation rate significantly decreased and apoptosis rate significantly increased.
Nutrition and cancer  •  2015  |  View Paper
Quercetin and vincristine are both active against ER− breast cancers and exhibit synergism in vitro.
Anti-cancer drugs  •  2010  |  View Paper
Pentamethyl, pentaethyl, pentapropyl and pentaallyl ethers of morin and quercetin (20 microM) all increased the uptake of [3H]vincristine by K562/ADM cells, while quercetin, morin and their pentabutyl ethers had no effect.
Cancer letters  •  2002  |  View Paper
In intact MRP1-overexpressing cells, quercetin reduced vincristine resistance from 8.9- to 2.2-fold, whereas kaempferol and naringenin had no effect.
Molecular pharmacology  •  2001  |  View Paper
These results show that in rats, quercetin may have a protective effect against peripheral neurotoxicity caused by vincristine.
Neurotoxicology  •  2020  |  View Paper
However, treatment of both vincristine and quercetin for a similar period reduced the serum CK-MB, LDH, SGPT and cTnT levels near to normal levels in ISO-treated rats.
In conclusion, the present finding appears to be the first one, suggesting a better protection of cardiac tissues by combined treatment of vincristine and quercetin in isoproterenol-induced cardiac toxicity.
Cardiovascular Toxicology  •  2014  |  View Paper
We conclude that low concentrations of quercetin indirectly activate the transport of [3H]vincristine by enhancing the phosphorylation (and hence activity) of P-glycoprotein, whereas high concentrations of quercetin inhibit P-glycoprotein.
European journal of pharmacology  •  2000  |  View Paper