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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The efflux mechanism related with P-glycoprotein also existed with the polar flavonoids; verapamil could enhance the permeation of rutin and quercetin via inhibition of P-glycoprotein.”
Transport of active flavonoids, based on cytotoxicity and lipophilicity: an evaluation using the blood-brain barrier cell and Caco-2 cell models.“Compared with the control group (given verapamil alone), the Cmax and AUC of verapamil increased approximately twofold in the rabbits pretreated with 15 mg kg−1 quercetin.”
“Consequently, absolute and relative bioavailability values of verapamil in the rabbits pretreated with quercetin were significantly higher (P<0.05) than those from the control group.”
“In conclusion, pretreatment of quercetin significantly enhanced the oral exposure of verapamil.”
“Metabolite‐parent AUC ratio in the rabbits pretreated with quercetin decreased by twofold compared with the control group, implying that pretreatment of quercetin could be effective to inhibit the CYP3A4‐mediated metabolism of verapamil.”
“This suggested that concomitant use of quercetin or a quercetin‐containing dietary supplement with verapamil requires close monitoring for potential drug interaction.”
“While co‐administration of quercetin concurrently was not effective to enhance the oral exposure of verapamil , pretreatment of quercetin 30 min before verapamil administration significantly altered the pharmacokinetics of verapamil.”
The effect of quercetin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rabbits“ Verapamil , a P-glycoprotein inhibitor, inhibited the efflux of [3H]vincristine from MBEC4 cells, while 10 microM quercetin significantly stimulated it.”
“Tangeretin, galangin, kaempferol, quercetin , and morin significantly reversed the ATPase activity stimulated by verapamil.”
Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells.
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