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Last Updated: 8 months ago

Possible Interaction: Quercetin and Verapamil

supplement:

Quercetin

Research Papers that Mention the Interaction

The efflux mechanism related with P-glycoprotein also existed with the polar flavonoids; verapamil could enhance the permeation of rutin and quercetin via inhibition of P-glycoprotein.
Toxicology in vitro : an international journal published in association with BIBRA  •  2014  |  View Paper
Compared with the control group (given verapamil alone), the Cmax and AUC of verapamil increased approximately twofold in the rabbits pretreated with 15 mg kg−1 quercetin.
Consequently, absolute and relative bioavailability values of verapamil in the rabbits pretreated with quercetin were significantly higher (P<0.05) than those from the control group.
In conclusion, pretreatment of quercetin significantly enhanced the oral exposure of verapamil.
Metabolite‐parent AUC ratio in the rabbits pretreated with quercetin decreased by twofold compared with the control group, implying that pretreatment of quercetin could be effective to inhibit the CYP3A4‐mediated metabolism of verapamil.
This suggested that concomitant use of quercetin or a quercetin‐containing dietary supplement with verapamil requires close monitoring for potential drug interaction.
While co‐administration of quercetin concurrently was not effective to enhance the oral exposure of verapamil , pretreatment of quercetin 30 min before verapamil administration significantly altered the pharmacokinetics of verapamil.
The Journal of pharmacy and pharmacology  •  2004  |  View Paper
Verapamil , a P-glycoprotein inhibitor, inhibited the efflux of [3H]vincristine from MBEC4 cells, while 10 microM quercetin significantly stimulated it.
European journal of pharmacology  •  2000  |  View Paper
Tangeretin, galangin, kaempferol, quercetin , and morin significantly reversed the ATPase activity stimulated by verapamil.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2021  |  View Paper