“ Quercetin significantly increases the plasma concentration of valsartan and peak concentration (70.45 µg/mL) was achieved at 3.5 h. In vitro studies were performed on rat intestinal everted sacs.”
“The simultaneous administration of quercetin significantly increases the intestinal absorption and decreases the efflux of valsartan.”
“The … valsartan from serosal side to mucosal side decreased from 53.12 ± 1.… 40.15 ± 0.45 µg/mL in the presence of quercetin and from 53.12 ± 1.27 to 28.68 ± 0.31 µg/mL … presence of verapamil (standard P-glycoprotein (P-gp) inhibitor) at 120 min.”