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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quercetin
Research Papers that Mention the Interaction
“The structure showed that quercetin binds to the specific substrate binding pocket (S1 pocket) of uPA mainly through its two neighboring phenolic hydroxyl groups.”
A structural mechanism of flavonoids in inhibiting serine proteases.“It is concluded from these data that inhibition … migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-κB and uPA , resulting in inhibition of MMP-2 and MMP-9 signaling.”
“ Quercetin downregulates uPA , uPAR and EGF, EGF‐R mRNA expressions.”
“ Quercetin inhibited calcium dependent urokinase activity and hence may prove to be an effective antimetastatic agent.”
“Recently, multiple anticancer effects of quercetin have been described, including inhibitory activity against uPA.”
Antimetastatic Potential of Quercetin Analogues with Improved Pharmacokinetic Profile: Pharmacoinformatic Preliminary Study.
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