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Last Updated: 8 months ago

Possible Interaction: Quercetin and Urokinase-Type Plasminogen Activator

Research Papers that Mention the Interaction

The structure showed that quercetin binds to the specific substrate binding pocket (S1 pocket) of uPA mainly through its two neighboring phenolic hydroxyl groups.
Food & function  •  2017  |  View Paper
It is concluded from these data that inhibition … migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-κB and uPA , resulting in inhibition of MMP-2 and MMP-9 signaling.
Anticancer research  •  2013  |  View Paper
Quercetin downregulates uPA , uPAR and EGF, EGF‐R mRNA expressions.
Cell biochemistry and function  •  2011  |  View Paper
Quercetin inhibited calcium dependent urokinase activity and hence may prove to be an effective antimetastatic agent.
Chemotherapy  •  2006  |  View Paper
Recently, multiple anticancer effects of quercetin have been described, including inhibitory activity against uPA.
Anti-cancer agents in medicinal chemistry  •  2021  |  View Paper