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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Quercetin and Tolbutamide



Research Papers that Mention the Interaction

Tolbutamide oxidation by the marmoset liver microsomes and the recombinant P450 M-2C was inhibited most effectively by quercetin , a CYP2C8 inhibitor, followed by omeprazole, a CYP2C19 inhibitor, whereas sulfaphenazole, a CYP2C9 inhibitor, was less potent under the conditions used.
Biochemical pharmacology  •  2006  |  View Paper
Quercetin showed marked inhibitory effects on both tolbutamide 4-methylhydroxylation and testosterone 6β-hydroxylation with IC50 values of 35 and 38 μmol/L, respectively.
American journal of therapeutics  •  2004  |  View Paper