“Metabolomics revealed that quercetin improves the oral bioavailability of ticagrelor might rely on changing the metabolic pathways of phenylalanine, tyrosine and tryptophan and the biosynthetic pathway of bile acids.”
“The research results at the metabolic level provide us with a strong basis and direction for further exploring the mechanism of quercetin enhancing the bioavailability of ticagrelor , and this may be useful for finding new agents that enhance the bioavailability.”
“This study compared the effects of quercetin, luteolin and catechin on the pharmacokinetic parameters of ticagrelor and found that quercetin can significantly increase the Cmax and AUC0-36 of ticagrelor , that is, quercetin can enhance the bioavailability of ticagrelor, but luteolin and catechin cannot.”