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Last Updated: 8 months ago

Possible Interaction: Quercetin and Tamoxifen

supplement:

Quercetin

Research Papers that Mention the Interaction

In summary, the findings of the present study suggest that quercetin when associated with tamoxifen decreases in plasma glucose levels.
The BuChE activity decreased in the … at all tested doses of quercetin coadministered … tamoxifen (P < .01); however, in adipose tissue, there was a biphasic activity with a decrease (P < .05) and increase (P < .05) in activity at doses of 7.5 and 22.5 mg.kg-1 b.w.
Journal of medicinal food  •  2017  |  View Paper
These findings indicate that tamoxifen inhibits CWR22 prostate tumor by modulating the angiogenesis and its antineoplastic effects can be potentiated by combined use with quercetin.
International journal of oncology  •  2004  |  View Paper
This suggests that quercetin can reverse tamoxifen resistance in breast cancer cells.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology  •  2015  |  View Paper
Combinations of ERbeta ligands such as estradiol (E(2)), 17 epiestriol (17E(3)), quercetin (Q) with tamoxifen (TMX) showed marked growth inhibition.
Cancer letters  •  2000  |  View Paper
Competition analysis showed that the anti‐estrogen tamoxifen and the flavonoids quercetin and rutin competed for (3H)‐E2 binding to type‐II EBS.
International journal of cancer  •  1990  |  View Paper
If the results are further confirmed in the clinical trials, the tamoxifen dosage should be adjusted when tamoxifen is administered with quercetin or quercetin-containing dietary supplements in order to avoid potential drug interactions.
The absolute bioavailability (AB%) of tamoxifen with 2.5 and 7.5 mg/kg quercetin ranged from 18.0% to 24.1%, which was significantly higher than the control group, 15.0% (p < 0.05).
The coadministration of quercetin (2.5 and 7.5 mg/kg) significantly (p < 0.05) increased the absorption rate constant (K(a)), peak concentration (C(max)) and the areas under the plasma concentration-time curve (AUC) of tamoxifen.
The enhanced bioavailability of tamoxifen as a result of its coadministration with quercetin might be due to the effect of quercetin promoting the intestinal absorption and reducing the first-pass metabolism of tamoxifen.
The relative bioavailability (RB%) of tamoxifen coadministered with quercetin was 1.20-1.61 times higher than the control group.
This suggests that quercetin inhibits the both MDR transporters efflux and first-pass metabolism of tamoxifen.
International journal of pharmaceutics  •  2006  |  View Paper
Tamoxifen , in turn, significantly increased muscle relaxation at all quercetin concentrations.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society  •  2021  |  View Paper