Possible Interaction: Quercetin and Sulforaphane

“Importantly, combination of quercetin with sulforaphane , an isothiocyanate enriched in broccoli, had synergistic effects.”

“Moreover, quercetin prevented expression of proteins involved in the epithelial-mesenchymal transition, which was even stronger in presence of sulforaphane , suggesting the blockade of signaling involved in early metastasis.”

“The objectives of this study were to examine the molecular mechanisms by which sulforaphane (SFN, an active compound in cruciferous vegetables) inhibits self-renewal capacity of pancreatic cancer stem cells (CSCs), and synergizes with quercetin , a major polyphenol and flavonoid commonly detected in many fruits and vegetables.”

“In the present study, we report for the first time that quercetin and sulforaphane in combination inhibit the proliferation and migration of melanoma (B16F10) cells more effectively than either compound used alone.”

“Taken together, our findings revealed that the administration of quercetin and sulforaphane in combination rather than alone may be a more effective approach for the treatment of malignant melanoma.”