Possible Interaction: Quercetin and Substance P

“ Quercetin also attenuated OVA induced MC degranulation, eosinophil number, substance P concentrations, and mRNA IL-4/TNF-α expression in the conjunctival tissue of AC models.”

“C48/80, a histamine promoter, and Substance P (a neuropeptide) EC50 was higher when combined with Quercetin compared to the EC50 of these compounds alone, suggesting that Quercetin could inhibit Mrgprx2‐induced pseudo‐allergic reaction.”

“Oral administration of quercetin at more than 25 mg/kg for 5 days significantly inhibited the increase in SP , CGRP and NGF contents in nasal lavage fluids induced by TDI nasal challenge.”

“These results suggest that quercetin potentiates plasma extravasation induced by substance P and bradykinin, and that this may result from inhibition of the degradative enzymes of these peptides.”

“Further results suggested that the PE induced by SP in the dura mater was enhanced by pretreatment with quercetin , similar to that observed with selective peptidase inhibitors.”

“The present study demonstrates that quercetin potentiates the PE induced by substance P in the urinary bladder.”

“Results showed that Quercetin at 25 mg/kg and 50 mg/kg could significantly (p < .05) increase the intestinal transit rate, motilin, gastrin, substance P levels, and concentration of short‐chain fatty acids (SCFAs), reduce the somatostatin levels, and improve the gastrointestinal peristalsis of rats.”