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Last Updated: 8 months ago

Possible Interaction: Quercetin and Serotonin

supplement:

Quercetin

Research Papers that Mention the Interaction

In the previous studies, we demonstrated that quercetin inhibits both glycine and 5-hydroxytryptamine type 3, (5-HT3A) receptor channel activities expressed in Xenopus oocytes.
Biological & pharmaceutical bulletin  •  2008  |  View Paper
Quercetin and 12 other natural flavonoid aglycones inhibit washed human platelet aggregation and secretion of serotonin induced by ADP, collagen or thrombin.
Agents and Actions  •  2005  |  View Paper
The metabolism of 5-HT was increased in Quer treated stressed than unstressed animals.
Physiological research  •  2018  |  View Paper
Results showed that serotonin and quercetin bind in the same region of the active site with a similar binding energy but quercetin has a much bigger inhibition constant.
Therefore, it seems possible that quercetin may act as a natural inhibitor of the receptor blocking the acute inflammation generated by serotonin.
European Biophysics Journal  •  2009  |  View Paper
Among the flavonoids examined, luteolin and quercetin significantly reduced the cellular 5-hydroxytryptamine concentration.
Journal of clinical biochemistry and nutrition  •  2021  |  View Paper