Possible Interaction: Quercetin and Rutin

“Results: The overall kinetic behaviour of quercetin differed remarkably after ingestion of quercetin aglycone or rutin.”

“We hypothesize that rutin RT ) and quercetin (QT) pharmacodynamically could act differently.”

“The release of QCT (21%, 3 h) was lower than that of QTR (51%, 3 h) and RUT (58%, 3 h).”

“ Rutin degraded during the process, giving quercetin.”

“RESULTS Proteasome activities following qu rcetin or rut in tr eatment were significantly augmented in comparison with non-treated cells.”

“Summary19 flavonoids of different structure added to an in vitro system remarkably inhibited the catechol-O-methyltransferase of human … most potent inhibitors being compouns with catechol structure of the side ring B. 50% inhibition is achieved by rutin in a molar ratio of … (flavonoid to norepinephrine), by quercetin of ….”

“The inhibition by quercetin and rutin is competitive, the inhibition by isorhamnetin is of mixed type.”

“ Rutin … quercetin as well as rutin and rosmarinic acid acted additively (CI = 0.096 and 1.06, respectively), while rutin and chlorogenic acid demonstrated slight synergism (… = 0.88) and rosmarinic acid with quercetin and rosmarinic acid with chlorogenic acid showed moderate antagonism (CI = 1.45 and 1.25, respectively).”

“The results clearly demonstrate a higher systemic availability of quercetin from OB extract and rutin.”

“Supplementation of pure rutin , but not of rutin contained in buckwheat seeds, increased the plasma quercetin content.”

“The mixture of rutin and quercetin seems to favour the accumulation of quercetin and/or its conjugated derivatives in the brain.”