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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Quercetin showed the strongest effect by improving the intracellular accumulation of ritonavir by 76.9 %.”
“… quercetin in the co-administration group and in … plasma concentration-time curve (AUC0–t) of ritonavir by 42.2 % (p < 0.05) and 53.5 % (p < 0.01), and decreased the peak plasma … < 0.05) and 45.8 % (p < 0.01), respectively, compared to the control group (ritonavir alone).”
Effect of quercetin on the transport of ritonavir to the central nervous system in vitro and in vivo“In vitro studies from our laboratory suggest that short-term exposure with pure herbal agents such as hypericin, kaempferol and quercetin or extract of SJW resulted in higher uptake or influx of ritonavir and erythromycin.”
“ Quercetin , hypericin, and kaempferol exhibited a remarkable inhibition of P-gp–mediated efflux of ritonavir by increasing its cellular uptake in these models.”
“There was a significant decrease in the Apical to Basal/Basal to Apical (AP-BL/BL-AP) transport ratio of ritonavir in presence of hypericin, kaempferol, and quercetin.”
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