Possible Interaction: Quercetin and Resveratrol

“In rats, an in vivo pharmacokinetics study revealed that the area under the curve of the self-microemulsifying formulation containing quercetin and resveratrol increased approximately ninefold for quercetin and threefold for resveratrol compared with the unformulated compounds.”

“Interestingly, quercetin and resveratrol , representing two major bio-active polyphenols, exhibit synergistic anti-proliferative effects.”

“Furthermore, resveratrol in combination with genistein and quercetin synergistically decreased adipogenesis in murine and human adipocytes.”

“Most important, resveratrol and quercetin chronically administered presented a strong synergism in inducing senescence‐like growth arrest.”

“Combination of 10 μM concentration of each resveratrol and quercetin brought additive effect on cellular growth, DNA damage, S-phase cell cycle arrest, and cell death in Cal-33 cells but not in the HEK-293 cells.”

“Conclusively, combination of resveratrol and quercetin brings cell growth inhibition, DNA damage, and cell cycle arrest in OCCs but not in normal cells.”

“Hence, resveratrol combined with quercetin may have better effects on it.”

“Strikingly, when RSV is combined with QCT , it promotes a potent reduction of QCT-induced autophagy and influences proapoptotic signaling.”

“ Resveratrol and quercetin (RQ) in combination (1:1 ratio) previously inhibited growth in human leukemia cells.”

“This up-regulation could be partially avoided by the addition of verbascoside or resveratrol , while treatment with quercetin resulted in a further increase in the expression of these genes.”

“The electron donating ability of resveratrol is slightly less than that observed with quercetin.”