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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Quercetin and Quetiapine

supplement:

Quercetin

Research Papers that Mention the Interaction

All the animals pre-treated with QCN , succumbed to death within 3–5 min of intravenous dosing of QTE (1 mg/kg).
Caution is advised for concomitant use of QCN rich dietary supplements with QTE.
The brain to plasma ratio of QTE increased upon QCN pre-treatment (2.6 vs 7.7), which could be attributed to P-glycoprotein inhibition at the blood–brain barrier by QCN.
The current set of studies indicated that serious herb–drug interaction between QCN and QTE might occur when they are co-administered.
The results showed a significant (p < 0.05) increase in exposure of QTE (peroral dosed) in the animals pre-treated with QCN as compared to the control group.
The studies in rat liver S9 fraction indicated that QCN could increase the metabolic stability of QTE by inhibiting the activity of CYP enzymes.
Xenobiotica; the fate of foreign compounds in biological systems  •  2020  |  View Paper