Possible Interaction: Quercetin and Piperine

“Down regulation of CYP3A37 and MDR1 mRNA in liver and duodenum indicate the combined pretreatment of piperine and quercetin may be useful for improving the pharmacokinetics of orally administered drugs which are substrates for CYP3A37 and MDR1.”

“The neuroprotective enhancement of QC along with piperine is attributed through antioxidant, anti-inflammatory and preventing neurotransmitter alteration mechanisms.”

“Co-administration of piperine with quercetin significantly elevated their potential to restore these behavioral, biochemical and molecular changes associated with mouse model of CUS.”

“These results suggest that piperine enhances the neuroprotective effects of quercetin against CUS-induced oxidative stress, neuro-inflammation and memory deficits.”

“However, combination of quercetin (25 mg/kg) with piperine (2.5 mg/kg) significantly enhanced its neuroprotective effect as compared with treatment with quercetin alone.”

“The study concluded that combination of quercetin with piperine contributed to superior antioxidant, anti-inflammatory, and neuroprotective effect against rotenone- and iron supplement–induced PD in experimental rats.”

“These findings indicate that piperine can enhance the antioxidant and anti-inflammatory properties of QC , and QC in combination with piperine exhibits strong neuroprotective effects against MPTP-induced neurotoxicity.”

“… QC (25 and 50 mg/kg) and … (25 mg/kg) in combination with piperine (2.5 mg/kg), in particular the combination therapy, significantly improved MPTP-induced behavioral abnormalities in rats, reversed … abnormal alterations of neurotransmitters in the striatum, and alleviated oxidative stress and inflammatory response in the striatum.”