Possible Interaction: Quercetin and Naringenin

“Moreover, the level of phase II metabolites in perfusion, plasma and bile samples increased when naringenin and quercetin were administered together.”

“These data demonstrate that low doses of naringenin and quercetin acutely and potently impair glucose homoeostasis.”

“Catechin showed partial agonistic activity, while quercetin and naringenin appeared to be antagonistic.”

“… quercetin inhibited NO production, as measured by nitrite formation at 10-100 microM. The most active … inhibitor, had an IC50 value of 0.09 microM. In contrast, flavanones, such as naringenin , and flavonoid glycosides, such as apiin, did not demonstrate … depended upon the substitution patterns of the flavonoid molecules.”

“Thirteen flavonoids (i.e., eriocitrin, narirutin, neohesperidin, quercitrin, eridictyol, didymin, naringenin , luteolin, sinensetin, nobiletin, tangeretin, naringin, and hesperidin) were fairly stable whereas quercetin was degraded significantly by US treatment.”

“Increased test concentrations of quercetin and catechin resulted in 51% and 126% greater ORAC values, but decreased naringenin by 68%.”

“Both the stimulatory effect of naringenin and the inhibitory effect of quercetin on nodule number were more pronounced at earlier stages of nodule development as revealed with specific staining of initial nodules.”