Possible Interaction: Quercetin and Myricetin

“From comet assay results it is observed that quercetin and myricetin when used in combination induce higher DNA damage in K562 leukemic cells than when tested individually.”

“ Quercetin inhibited BFC activity in human recombinant cDNA-expressed CYP3A4 competitively with the Ki=15.4±1.52μM, and myricetin - noncompetitively with the Ki=74.6±7.99μM. The degree of inhibition by quercetin was similar between genders.”

“Transepithelial electrical resistance (TER) across the monolayers increased rapidly during incubation with quercetin , peaking at 6 h. Lucifer yellow flux, a paracellular marker, was dose-dependently lower after quercetin and myricetin treatments, although quercetin exhibited a more potent effect.”

“These results highlight quercetin , kaempferol, and myricetin as dietary-derived inhibitors of Met activity and suggest that this inhibitory effect may contribute to the chemopreventive properties of these molecules.”

“Colony assay revealed that myricetin had the strongest inhibitory effect on cell transformation among three flavonols including myricetin, quercetin and kaempferol.”

“Amoung quercetin, myricetin , kaempferol, isorhamnetin, curcumin, hesperidin, or astaxanthin in the range of 10−7–10−5 M, culture with quercetin (10−6 or 10−5 M) caused a significant increase in diaphyseal calcium content.”

“Further in vivo studies showed that a single topical application of tannic acid, quercetin , and myricetin greatly diminished epidermal AHH (53-65%), ethoxycoumarin O-deethylase (30-68%), and ethoxyresorufin O-deethylase (66-97%) activities whereas anthraflavic acid was ineffective in this regard even when repeatedly applied.”

“The myricetin level in ripe fruits of cultivated blueberries and the quercetin level in ripe berries of privet was higher than in unripe.”