“The … with quercetin , the Cmax (2.16 ± 0.40 vs. 1.33 ± 0.21 mg/… ± 1.22 vs. 7.34 ± 0.75 mg·h/L) of losartan increased significantly (p < .05), and while the Cmax (0.76 ± 0.…/L) of EXP3174 decreased significantly compared to the control (p < .05).”
“These results indicated that the herb–drug interaction between quercetin and losartan might occur when they are co-administered in rats, quercetin could increase the systemic exposure of losartan and decrease the plasma concentration of EXP3174, possibly by inhibiting the activity of P-gp or CYP450 enzyme.”