Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Quercetin and Lonidamine

supplement:

Quercetin

Research Papers that Mention the Interaction

In addition, while lonidamine induced a cell cycle arrest in the G2/M phase, administration of quercetin and its combination with lonidamine arrested the cell division at S point, indicating the synergistic strength of quercetin on cytotoxicity.
In this study, the combination of quercetin and lonidamine has been evaluated for the first time and the combination treatment decreased MMP-2/-9 mRNA expression more potently than the effects of the compounds alone.
The combination of quercetin and lonidamine significantly induced apoptosis of MCF-7 cells (p<0.0001) and increased caspase levels (p<0.0001).
The results showed that lonidamine was more effective when combined with quercetin , and their combination may be a candidate for a novel strategy of treatment for breast cancer.
Anais da Academia Brasileira de Ciencias  •  2020  |  View Paper