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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Quercetin and Lonidamine



Research Papers that Mention the Interaction

In addition, while lonidamine induced a cell cycle arrest in the G2/M phase, administration of quercetin and its combination with lonidamine arrested the cell division at S point, indicating the synergistic strength of quercetin on cytotoxicity.
In this study, the combination of quercetin and lonidamine has been evaluated for the first time and the combination treatment decreased MMP-2/-9 mRNA expression more potently than the effects of the compounds alone.
The combination of quercetin and lonidamine significantly induced apoptosis of MCF-7 cells (p<0.0001) and increased caspase levels (p<0.0001).
The results showed that lonidamine was more effective when combined with quercetin , and their combination may be a candidate for a novel strategy of treatment for breast cancer.
Anais da Academia Brasileira de Ciencias  •  2020  |  View Paper