Possible Interaction: Quercetin and Leptin

“Our results showed that Ob-… significantly after 500 ng/mL leptin exposure (1.8x, 1.5x, 6.2x … were reduced by addition of 125 uM quercetin (0.7x, 0.3x and 0.4x for Ob-Ra, ERK1/2 … suppress leptin-induced TNF-alpha secretion (3.8x) by 0.8x.”

“Supplementation with quercetin suppressed the increase in the number of macrophages, the decrease in the ratio of CD4+ to CD8+ T cells in EAT, and the elevation of plasma leptin and tumor necrosis factor α levels in mice fed the Western diet.”

“Diabetes-related plasma biomarkers insulin, leptin , resistin, and glucagon were significantly reduced by quercetin supplementation.”

“Data analysis of real-time PCR showed that with increases in quercetin concentration, a decreasing trend was seen in mRNA levels of leptin of treated cells compared with the control cells (P < 0.05).”

“OBJECTIVE To investigate the possible inhibitory action of pure quercetin on secretion and gene expression of leptin in the T47D breast cancer cell line.”

“Conclusions: Considering the high prevalence of obesity, this observation provides a rationale for use of curcumin, quercetin and EGCG as antagonists of leptin in the treatment of obese breast cancer patients.”

“Increase in ERK1/2 phosphorylation in response to leptin was reduced by the addition of quercetin , curcumin and EGCG.”

“pioglitazone and hydroxy citric acid, the group treated with quercetin showed significant decrease in the levels of hyaluronic acid and leptin and significant decrease in adiponectin levels compared with that of experimentally induced NASH NASH group, offering maximum protection against NASH.”

“ Quercetin was confirmed to reduce serum insulin and leptin levels and blockade islet hyperplasia in fructose-fed rats.”

“These results demonstrate that quercetin protects β-cell mass and function under high-fructose induction through improving leptin signaling and preserving pancreatic Akt/FoxO1 activation.”