Possible Interaction: Quercetin and Kaempferol

“Most importantly, recent articles reported that combining luteolin with quercetin , as well as with celcoxib, had more potent anticancer effect than each one individually.”

“The results concerning DNA protective potential against free radicals in HMB-2 cells demonstrated that QU and LU have significant effect in dose dependent manner.”

“In apoptosis-related protein profiles, at least twofold reduction in various apoptotic proteins was observed after quercetin and kaempferol treatment, whereas a different profile was observed for GA.”

“Two flavonols, fisetin and quercetin, were somewhat less efficient in suppressing cellular viability, whereas baicalein, chrysin, (+)-… only a small or no response at doses as high as 100 μM. Both fisetin and quercetin were able to … activity of luteolin in both cell lines by … values up to four fold.”

“ Quercetin and luteolin considerably inhibited the appearance of this (–)-epicatechin conjugate both in the apical and basolateral compartments.”

“ Quercetin showed highly significant positive correlations with kaempferol (r = 0.59, p < .0001), oil% (r = 0.58, p< .0001), and oleic acid (r = 0.31, p < .001).”

“ Kaempferol produced a significant concentration-dependent decrease of iNOS, COX-2 and CRP protein level at all concentrations, but the percentage of inhibition induced by quercetin was reduced at high concentrations.”

“A trend in reduction of total cell counts was seen following a single exposure, a 4-day exposure or a 14-day exposure to quercetin and kaempferol.”

“Combined treatments with quercetin and kaempferol were more effective than the additive effects of each flavonol.”

“In conclusion, the synergistic antiproliferative effect of quercetin and kaempferol demonstrated in cultured human cells has broad implications for understanding the influence of dietary nutrients in vivo, where anticancer effects may be a result of nutrients which act in concert.”

“ Qu and Lu exhibited a specific action in hampering the levels of phosphorylation of this and the aforementioned proteins, while having no discernible effect on their synthesis.”

“Apoptosis was not evident, even when concentrations of quercetin or kaempferol were raised to 100 μM. The present studies suggest that alterations in cell cycle progression contribute significantly to the antiproliferative effects of quercetin and kaempferol in PC-3 cells.”